1. Screening for potential antifibrotic lead molecules in cultured liver stellate cells and in vivo.
Papers: Perumal N*, Perumal M*, et al., Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling. Biochimie 2017; 140, 10-19 (*Equal contribution). MadanKumar P, et al., Morin, a dietary flavonoid, exhibits anti-fibrotic effect and induces apoptosis of activated hepatic stellate cells by suppressing canonical NF-kappaB signaling. Biochimie 2015; 110: 107–18. MadanKumar P, et al., Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/b-catenin signaling, Toxicol. Appl. Pharmacol. 2014; 277 (2) 210e220.
2. Screening for potential anticancer lead molecules in cultured liver cancer cells and in vivo.
Papers: Perumal N, Perumal M, et al., Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/β-catenin and NF-κB signaling in Mst1 overexpressed HepG2 cells. Exp Cell Res. 2017; 355:124–141.
Lipid & cholesterol metabolism in human diseases; Liver stellate cell biology, Cancer cachexia.
Recognized by AcSIR as an Assistant Professor of the Academy in the Faculty of Biological Sciences during March 2018. Postdoctoral Research Fellowship in Drs. Brown/Goldstein laboratory, UT Southwestern Medical Center, Dallas, TX, USA for the period 2014-2017; Research Associate in a DBT funded project in University of Madras, Chennai during 2014 (not accepted*); Senior Research Scholarship (Science) by Lady Tata Memorial Trust, Mumbai, INDIA for the period 2010-2012; Travel Grant Award from Christian Medical College (CMC), Vellore for presenting a poster in the “Tenth CMC Winter symposium” during January 2012; Proficency Awards for studies in M.Sc Biochemistry during 2005-2007; Prof. S. Govindasamy Cash Prize Award for securing first mark in Biochemistry in B.Sc University Examination during 2002-2005.