1. Screening for potential antifibrotic lead molecules in cultured liver stellate cells and in vivo.
Papers: Perumal N*, Perumal M*, et al., Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling. Biochimie 2017; 140, 10-19 (*Equal contribution). MadanKumar P, et al., Morin, a dietary flavonoid, exhibits anti-fibrotic effect and induces apoptosis of activated hepatic stellate cells by suppressing canonical NF-kappaB signaling. Biochimie 2015; 110: 107–18. MadanKumar P, et al., Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/b-catenin signaling, Toxicol. Appl. Pharmacol. 2014; 277 (2) 210e220.
2. Screening for potential anticancer lead molecules in cultured liver cancer cells and in vivo.
Papers: Perumal N, Perumal M, et al., Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/β-catenin and NF-κB signaling in Mst1 overexpressed HepG2 cells. Exp Cell Res. 2017; 355:124–141.
SREBPs in Obesity, Fatty liver and Cancer; Stellate cell biology.
Recognized by AcSIR as an Assistant Professor of the Academy in the Faculty of Biological Sciences during March 2018. Postdoctoral Research Fellowship in Drs. Brown/Goldstein laboratory, UT Southwestern Medical Center, Dallas, TX, USA for the period 2014-2017; Research Associate in a DBT funded project in University of Madras, Chennai during 2014 (not accepted*); Senior Research Scholarship (Science) by Lady Tata Memorial Trust, Mumbai, INDIA for the period 2010-2012; Travel Grant Award from Christian Medical College (CMC), Vellore for presenting a poster in the “Tenth CMC Winter symposium” during January 2012; Proficency Awards for studies in M.Sc Biochemistry during 2005-2007; Prof. S. Govindasamy Cash Prize Award for securing first mark in Biochemistry in B.Sc University Examination during 2002-2005.